Desmoid Tumors in the Active Surveillance Era: Evaluation of Treatment Options and Pain Relief in a Single-Center Retrospective Analysis

In patients with desmoid tumors (DT), active surveillance has been increasingly preferred over surgery, with treatment (including pharmacological therapy, radiotherapy, and/or surgery) being resorted to in cases of confirmed disease progression. This study aimed to evaluate event-free survival and pain management according to different treatment strategies. WeTo evaluated event-free survival including recurrence after initial surgical treatment or change in therapeutic management after initial non-surgical treatment and pain management according to different treatment strategies. All patients referred for DT in 2001–2021 at our institutions were stratified into the following four groups: those treated surgically prior to 2012 (SGPre12) or after 2012 (SGPost12), those treated pharmacologically (MG), and those under active surveillance (ASG).