DMDD

The DMDD programme was a 5 year project that ran from 2013-2018, funded by a Strategic Award from the Wellcome Trust. It goal was to study 'embryonic lethal' mouse mutations using a combination of high resolution 2D and 3D imaging, transcriptomics, histology and immunohistochemistry. Its aim was to advance efforts to understand why loss of individual 'embryonic lethal' genes has such profound effects on embryo development and survival. Embryo image data was analysed by anatomical experts and abnormal phenotypes annotated using the Mouse Phenotype (MP) standard ontology. All data obtained during the course of the project are freely available from the DMDD web site.

DMDD项目是一项为期5年的研究计划，于2013年至2018年实施，由惠康信托基金（Wellcome Trust）的战略研究奖提供资助。该项目的目标是结合高分辨率二维（2D）与三维（3D）成像技术、转录组学、组织学及免疫组织化学方法，研究“胚胎致死（embryonic lethal）”小鼠突变体，其核心宗旨是深化对单个“胚胎致死”基因缺失为何会对胚胎发育与存活产生显著影响的理解。胚胎影像数据由解剖学专家开展分析，并采用小鼠表型（Mouse Phenotype，MP）标准本体对异常表型进行注释。本项目实施过程中产生的全部数据均可通过DMDD官方网站免费获取。

搜集汇总

背景与挑战

背景概述

DMDD是一个由Wellcome Trust资助、于2013年至2018年运行的研究项目，旨在通过高分辨率成像、转录组学和组织学等方法，研究胚胎致死性小鼠基因突变对胚胎发育和生存的影响。项目数据已由解剖专家分析，并采用标准本体进行表型注释，所有数据均可从DMDD网站公开获取。