Dataset related to the article "Redefining the risk of major arrhythmic events in non-ischaemic cardiomyopathy: insights from the DERIVATE-NICM study"

This record contains raw data related to the article "Redefining the risk of major arrhythmic events in non-ischaemic cardiomyopathy: insights from the DERIVATE-NICM study" Aims: Selection of the patients for implantable cardioverter defibrillator (ICD) primary prevention therapy in non-ischemic cardiomyopathy (NICM) needs to be improved. To evaluate the additional prognostic value of a new cardiac magnetic resonance (CMR) score based on late gadolinium enhancement (LGE) pattern distribution (DERIVATE Risk Score 2.0) as compared to previously published DERIVATE Risk Score 1.0, which is based solely on quantitative parameters, in a cohort of NICM patients enrolled in the DERIVATE registry Methods and Results: 1384 NICM patients with chronic heart failure (HF) and left ventricular ejection fraction (LVEF)<50% were evaluated for primary sudden cardiac death (SCD) prevention therapy. Major adverse arrhythmic cardiac events (MAACE) were the primary endpoint. (www.clinicaltrials.gov:RCT#NCT03352648). During a median follow-up of 959 days, MAACE occurred in 128 (9.2%) patients. In the multivariate analyses, male gender (HR: 1.605 [95% CI: 1.051-2.451]; p:0.028), LVEF per point % (HR:0.977[95%CI:0.961-0.993); p:0.005) and presence and location of midwall LGE (weighted HR:1.066 [95%CI:1.045-1.086), p<0.001) were independent predictors of MAACE. A multiparametric CMR weighted predictive derived score (DERIVATE Risk Score 2.0) provided a higher additional prognostic value vs TTE-LVEF cut-off of 35% as compared to the previous published DERIVATE Risk Score 1.0 with a net reclassification improvement (NRI) of 54.52% (CI95%: 36.52%-72.52%; p<0.001). These findings were confirmed in the validation cohort.Conclusions: The presence of midwall LGE but also the location of scar confers an added and independent MAACE risk to a large NICM population influencing the choice of treatment.