Figure S1 - Evaluation of Cost-Effective Strategies for Rabies Post-Exposure Vaccination in Low-Income Countries

Cost of vaccination per rabies death averted (life saved) for different PEP regimens according to clinic throughput and assuming imperfect vaccine use (4×0.1 mL injections from a 0.5 mL vial, and 8×0.1 mL injections from a 1 mL vial). Costs for IM administered vaccinations (the Zagreb regimen and the Essen 4-dose reduced regimen are exactly equivalent and shown in black) and ID administered vaccinations (the updated TRC regimen is shown in blue, the 4-site in red, and the 1-week in grey) per rabies death averted is plotted against clinic throughput (the number of new animal bite patients presenting for PEP vaccination each month). Shading represents 99% confidence intervals resulting from variation in patient arrival dates and the effects on vial sharing. Dashed lines highlight optimal vaccine use in high throughput clinics. Panel A is based on 0.5 mL vials and panel B on 1 mL vials. Note the x-axis is plotted on a log scale. (0.03 MB PS)