The selectivity of Dp44mT relative to the 5 most potent anti-cancer TSCs, namely 1b, 1d, 2b, 2f and 3c, was examined by calculating their “therapeutic indices”.
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The latter was calculated by dividing the NHDF cell IC50 by the IC50 of the neoplastic HCT116 p53+/+ or HCT116 p53−/− cell-types.The selectivity of Dp44mT relative to the 5 most potent anti-cancer TSCs, namely 1b, 1d, 2b, 2f and 3c, was examined by calculating their “therapeutic indices”.
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2015-12-02
