Human jak1 kinase domain in complex with inhibitor
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Human jak1 kinase domain in complex with inhibitor Descriptor: Tyrosine-protein kinase JAK1, ~{N}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{H}-indol-7-yl]-2-methyl-pyridine-3-carboxamide Authors: Read, J.A, Steuber, H. Deposit date: 2019-08-21 Release date: 2020-04-29 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor. J.Med.Chem., 63, 2020
创建时间：
2019-08-21
