Saccharomyces cerevisiae strain whole genome shotgun sequence

We performed phenotypic profiling and high coverage genome re-sequencing of 106 wild S. cerevisiae isolates from diversified natural sources including primeval forests remote from human activity and 160 domestic isolates associated with various fermentation processes including indigenous fermented foods in rural areas. We show that the diversity of the wild population with ten lineages is nearly double that of the domestic population with 12 lineages in China. The domestic lineages identified in this study together with the other domestic lineages isolated world-wide share a common recent ancestor, suggesting the origin of the domestic population through a single bottleneck .