BindingDB Entry 50026291: Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.

Small molecule binding data for protein Aurora kinase B/Inner centromere protein, Casein Kinase II, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4, Ephrin type-B receptor 4 (EphB4), Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Hepatocyte growth factor receptor, Insulin receptor, Insulin-like growth factor I receptor, Mitogen-activated protein kinase kinase kinase 8, NUAK family SNF1-like kinase 1, Platelet-derived growth factor receptor beta, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase PLK4, Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot O00444, O14965, O60285, P00533, P04626, P06213, P08069, P08581, P09619, P11802, P12931, P24941, P35916, P35968, P36888, P41279, P54760, P68400, Q02763, Q05397, Q541P7, and Q96GD4