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Dose escalation of Wnt stimulation during the exit from pluripotency identifies tranilast as a small molecule regulator of cardiac mesoderm differentiation

NIAID Data Ecosystem2026-05-02 收录

中内胚层分化

Wnt信号通路调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE246081 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-02-14

结直肠癌分子机制

Wnt信号通路调控

To determine the critical mediator of TRIB3-enhanced Wnt/beta-catenin signaling, we examined the expression profile of genes that might regulate Wnt/beta-catenin by using mRNA microarrays. Aberrant ac

NIAID Data Ecosystem60

TGFÃ-induced lncRNA LINC00313 activates Wnt signalling and promotes cholangiocarcinoma progression

胆管癌分子机制

Wnt信号通路调控

Cholangiocarcinoma (CCA) is a devastating liver cancer characterized by high aggressiveness and resistance to therapy, which results to poor prognosis. Signals imposed by oncogenic pathways, such as t

NIAID Data Ecosystem50

Early Insights into the Function of KIAA1199, a Markedly Overexpressed Protein in Human Colorectal Tumors

结直肠癌分子机制

Wnt信号通路调控

We previously reported that the expression of KIAA1199 in human colorectal tumors (benign and malignant) is markedly higher than that in the normal colonic mucosa. In this study, we investigated the f

Figshare2016-01-18 更新30

Importance of RAD6B in activation of canonical WNT signaling in melanoma development

黑色素瘤分子机制

Wnt信号通路调控

We have demonstrated that RAD6B, a ubiquitin conjugating enzyme that is a principal component of translesion synthesis pathway, stabilizes and transcriptionally activates beta-catenin by lysine 63-lin

NIAID Data Ecosystem60

Activation of Wnt Signaling by Chemically Induced Dimerization of LRP5 Disrupts Cellular Homeostasis

Wnt信号通路调控

肿瘤发生机制

Wnt signaling is crucial for a variety of biological processes, including body axis formation, planar polarity, stem cell maintenance and cellular differentiation. Therefore, targeted manipulation of

Figshare2016-01-18 更新40

Dose escalation of Wnt stimulation during the exit from pluripotency identifies tranilast as a small molecule regulator of cardiac mesoderm differentiation

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