The epigenetic Kit modification is maintained in the Dnmt2 −/− progeny of heterozygote parents but not further transmitted.

Analysis of 3 litters for each cross. In crosses #1 and 2, Kit genotypes are indicated in the Dnmt2 −/− fraction of the progeny. In cross #3, the male parent was a Dnmt2 −/− homozygote with a modified Kit allele born from cross #2. When mated with a wild type female, only non-modified Kit+ alleles were transmitted to the progeny.