Analysis of TC-mAb mice (Exp5: Allelic exclusion)
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The experiment had been performed to analyze B cell development of human antibody-procducing mice (TC-mAb mice). The flow cytometry experiment was designed to detect the subsets of human Igk and mouse Igl expressing B cells in the IgM+ spleen mature (CD19+CD93-IgM+) and immature (CD19+CD93+IgM+) B cells of 13 weeks-old mice. Notes: This experiment corresponds to Supplementary Figure 33-34 in the paper "Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci". Publication link: https://doi.org/10.21203/rs.3.rs-103241/v1
创建时间：
2022-03-01
