Dyslipidemia and Associated Factors among People Living with HIV on Dolutegravir-based Antiretroviral therapy in Central Uganda

This dataset accompanies a cross-sectional study that assessed the prevalence of and factors associated with dyslipidemia among adults living with HIV on dolutegravir (DTG)-based antiretroviral therapy (ART) in central Uganda. The research was guided by the hypothesis that DTG-based ART is associated with a high burden of dyslipidemia, and that specific demographic, clinical, and anthropometric characteristics may influence this risk. The data were collected from 281 systematically sampled adults who had been on DTG-based ART for at least six months, attending care at Kira Health Centre IV in Wakiso District.

The dataset includes information obtained through structured interviewer-administered questionnaires, medical record reviews, anthropometric measurements, and laboratory testing. Variables captured include age, sex, education, ART duration, lifestyle behaviors, comorbidities, viral load, body mass index, waist and hip circumference, and fasting lipid profiles including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. Data were collected by trained research assistants following standardized procedures, and all laboratory analyses were conducted in certified clinical laboratories.

The study found that 44.1% of participants had dyslipidemia, with low HDL cholesterol being the most common abnormality, affecting 39.9% of the sample. Elevated total cholesterol and LDL cholesterol were less common, affecting 5.7% and 5.0% of participants, respectively. Multivariable logistic regression analysis was used to identify associated factors, and waist circumference demonstrated a moderate ability to predict dyslipidemia with an area under the ROC curve of 0.577 (95% CI: 0.511–0.644).

This dataset provides valuable insight into the metabolic complications associated with modern HIV treatment regimens in sub-Saharan Africa. It highlights the need for routine lipid monitoring and risk assessment among patients on DTG-based ART. The data can be interpreted to explore associations between ART and cardiovascular risk, assess the predictive value of obesity indices, and inform guidelines on the management of non-communicable disease comorbidities in HIV care settings. Researchers, clinicians, and public health practitioners may find this dataset useful for secondary analyses, modeling, or policy development. Ethical approval was obtained, and all participants provided informed consent. The data have been anonymized and prepared for safe public sharing.