RNA-seq of primary tumors from Braf/Pten/Cre APOE2 and APOE4 mice

Genetic variation in the APOE gene modulates melanoma progression. To identify tumor cell-intrinsic mechanisms underlying differences in tumor progression between APOE2 and APOE4 genotypes, we crossed the Braf/Pten/Cre (BPC) genetically engineered mouse model with APOE2 (BPCE2) and APOE4 (BPCE4) knock-in mice. We performed RNA-Seq on tumors derived from these mice. This analysis revealed protein synthesis as a process that is enhanced by APOE2. **Note: Raw fastq sequencing files for these samples were irrevocably corrupted due to a server failure and therefore could not be provided. Kallisto transcript abundance estimates have been included as processed data.** RNA-seq was conducted on 4 tumors each from BrafV600E/+;Pten fl/fl;Tyr-CreERT2;APOE2 (BPCE2) and BrafV600E/+;Pten fl/fl;Tyr-CreERT2;APOE4 (BPCE4) mice.