PATHOLOGICAL-ANATOMICAL AND IMMUNOHISTOLOGICAL CHANGES IN CHRONIC SUPPURATIVE OTITIS MEDIA AND IMPROVEMENT OF TREATMENT APPROACHES

Chronic suppurative otitis media is a common inflammatory disease of the middle ear characterized by persistent purulent discharge, tympanic membrane perforation, and progressive pathological changes in the middle ear structures. The disease may lead to hearing loss and serious complications if not treated properly. This thesis analyzes pathological-anatomical and immunohistological changes in chronic suppurative otitis media and discusses ways to improve treatment effectiveness.