Stereoselective Synthesis of Pyrrolidines Containing a 3‑Fluoro Quaternary Stereocenter via Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition
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https://figshare.com/articles/dataset/Stereoselective_Synthesis_of_Pyrrolidines_Containing_a_3_Fluoro_Quaternary_Stereocenter_via_Copper_I_-Catalyzed_Asymmetric_1_3-Dipolar_Cycloaddition/5471542
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资源简介：
A highly efficient asymmetric 1,3-dipolar
cycloaddition of azomethine
ylides to β,β-disubstituted β-fluoroacrylates catalyzed
by a chiral N,O-ligand/Cu(CH3CN)4BF4 system is reported, affording chiral densely substituted
pyrrolidines with four contiguous stereocenters, including one fluorinated
quaternary stereocenter at the 3-position, in good to excellent yields
(up to 99%), with excellent levels of diastereo- and enantioselectivities
(dr >20:1; ee up to 99%).
创建时间：
2017-10-04
