UDEDB

To depict the landscape of molecular changes in the endometrium undergoing cyclic dynamic changes, we developed the Uterine Dynamic Expression Database (UDEDB), a comprehensive resource that integrates published literature, single-cell sequencing data from the Human Endometrial Cell Atlas (HECA), and our experimental bulk RNA sequencing data from both humans and mice. Through literature mining of PubMed and EuropePMC, UDEDB provides detailed descriptions of the 2,020 reported molecules, including PubMed IDs, species, molecular types, experimental verification methods and references to high-throughput sequencing data. To further elucidate the mechanisms driving these expression changes, we conducted literature mining and systematically curated 4,349 transcriptional regulatory entries for both humans and mice across different uterine stages. Additionally, it offers gene expression values and dynamic expression trends across various phases of the human endometrial menstrual cycle, as well as different stages in pseudo-pregnant mouse epithelia.