CORTICAL CONNECTIVITY OF THE DEFAULT MODE NETWORK AT ALPHA AND BETA OSCILLATIONS WAS REDUCED DURING TONIC PAIN- DIFFERENTIAL EFFECT OF EYE STATE

This is Granger causality (connectivity measure) data at alpha and gamma oscillations for four of the default mode network (DMN) connections: (1) right angular gyrus (RAG)-posterior cingulate cortex (PCC), (2) right angular gyrus (RAG)-medial prefrontal cortex (mPFC), (3) left angular gyrus (LAG)-posterior cingulate cortex (PCC), (2) left angular gyrus (LAG)-medial prefrontal cortex (mPFC). Data were collected from 28 subjects who were randomly and balanced assigned to two groups: (EC-EO) group and (EO-EC) group, depending on the order of the eye-states during EEG recording. All subjects experienced two conditions: Placebo and capsaicin (pain). For each condition, data were collected at two time points: baseline and 1 hour post placebo or capsaicin application. For each time point, data were collected during both eyes-closed and eyes-open states. In addition, the data shows subjective pain ratings on a numerical rating scale (NRS). Throughout the one-hour patch application, participants were asked to report their pain NRS ratings every 5 minutes. Three pain parameters were then calculated: average pain intensity across all the 5-minute NRS reports, current pain intensity as the pain NRS level reported at the end of one-hour patch application, and the peak pain intensity as the highest pain NRS score reported.