Development of a new model of Parkinson´s disease

To get insight the molecular mechanism underlying neuronal loss in Parkinson´s disease. We performed gene expression profiling analysis using data obtained from RNA-seq of midbrain of mice injected with an AAV control or an AAV expressing human tyrosinase that induces neuromelanin accumulation and subsequent neuronal loss. Overall design: Comparative gene expression profiling analysis of RNA-seq data of midbrain of mice injected with an AAV control or an AAV expressing human tyrosinase.