Crystal structure of SARS-CoV-2 Mpro in complex with RHTCR02

Crystal structure of SARS-CoV-2 Mpro in complex with RHTCR02 Descriptor: 3C-like proteinase nsp5, ~{tert}-butyl ~{N}-[1-[(2~{S})-1-[[(2~{R},3~{S})-4-azanyl-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]butan-2-yl]amino]-3-cyclopropyl-1-oxidanylidene-propan-2-yl]-5-fluoranyl-2-oxidanylidene-pyridin-3-yl]carbamate Authors: El kilani, H, Hilgenfeld, R. Deposit date: 2024-04-24 Release date: 2025-01-29 Last modified: 2025-02-26 Method: X-RAY DIFFRACTION (2.191 Å) Cite: Structure-Based Optimization of Pyridone alpha-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease. J.Med.Chem., 68, 2025