Genome-wide analysis of Olig2-positive and Olig2-negative tumors in a glioma mouse model.. Genome-wide analysis of Olig2-positive and Olig2-negative tumors in a glioma mouse model.

Analysis of genes differentially expressed in Olig2-positive (oligodendrocyte-like) versus Olig2-negative tumors. The hypothesis tested in the present study was that the glial phenotype influence the vasculature and the tumor microenvironment. Results provide evidence that multiple pathways including angiogenesis and immune response are differentially expressed between the two types of tumors. Overall design: Total RNA obtained from tumors from animals transplanted with Olig2cre/+;p53fl/fl;hEGFRvIII and Olig2cre/cre;p53fl/fl;hEGFRvIII cells, at the time of neurological symptoms appearance.