Product adherence and tolerability by treatment group as per protocol definitions.

*One enrolled participant was later found to not meet eligibility criteria and was subsequently discontinued from product use, one enrolled participant was erroneously thought to not meet eligibility criteria and was discontinued from product use, and one participant was discontinued from product use by the site PI after completing her Day 14 visit.†These participants were subsequently discontinued from product due to closure of trial.‡This participant took all 28 doses in 16 days, but missed one or both doses on three days, and thus was not adherent per the protocol definition.