Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation

ChEBI2010-04-30 更新2026-07-21 收录

干细胞重编程

生殖细胞发育

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-18813 数据链接链接失效反馈

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Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation

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2010-04-30

Tdrd6a recruits Ziwi-bound piRNAs and coordinates deposition of germ plasm mRNAs into primordial germ cells [RIP-Seq]. Danio rerio

生殖细胞发育

piRNA调控

Germ plasm, the Balbiani body and nuage are evolutionary conserved structures essential for germ cell specification and maintenance. We describe Tdrd6a as a component of these structures with two dist

NIAID Data Ecosystem80

Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]. Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]

干细胞重编程

染色质可及性调控

Chemical induction of pluripotency (CIP) is an ideal way to reprogram cell fate, but remains poorly understood. Here we report the development of an efficient CIP protocol and the chromatin accessibil

NIAID Data Ecosystem40

10X Genonics Drop-seq single-cell RNA-seq of neonatal (P1.5) testis cells from mice treated with DMSO or Retinoic Acid.

单细胞转录组学

生殖细胞发育

To reveal distinct transcriptomes associated with response of neonatal prospermatogonia to retinoic acid (RA), unselected testis cells from animals treated with RA or DMSO were used for Drop-Seq analy

NIAID Data Ecosystem30

Transcription factor NKX3-1 is required for reprogramming to pluripotency and can replace OCT4 in mouse and human iPSC induction [ATAC-seq]. Homo sapiens

干细胞重编程

转录因子功能

Resolution of early molecular events preceding endogenous OCT4 activation is critical to understanding the mechanism of reprogramming somatic cells to induced pluripotent stem cells (iPSCs), yet captu

NIAID Data Ecosystem40

α-Ketoglutarate inhibits the pluripotent-to-totipotent state transition

干细胞重编程

代谢调控机制

In early mouse embryogenesis, the distinct enrichment of α-ketoglutarate (αKG) in blastocysts and L-2-hydroxyglutarate (L-2HG) in 2-cell (2C) embryos serves as a key metabolic signature. While elevate

NIAID Data Ecosystem30

Metastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation

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