mouse fecal bolus Raw sequence reads

The gut microbiome and the gut brain axis are potential determinants of Alzheimer's disease (AD) etiology or severity and gut microbiota might coordinate with the gut-brain axis to regulate behavioral phenotypes in AD mouse models. Using 6-month-old human amyloid precursor protein (hAPP) knock-in (KI) mice, which contain the Swedish and Iberian mutations (AppNL-F) or the Arctic mutation included as third mutation (AppNL-G-F), behavioral and cognitive performance is associated with the gut microbiome and APP genotype modulates this association.