NUMB:ITCH ubiquitinates GLI1

GLI1 is ubiquitinated by ITCH and subsequently degraded by the proteasome. ITCH-mediated degradation of GLI1 does not depend on the Dc or Dn degrons required for interaction with beta-TrCP, but instead relies on a novel PPXYs/pSP degron of GLI1 (di Marcotullio et al, 2006, 2011; Huntzicker et al, 2006).

GLI1 被ITCH泛素化，随后被蛋白酶降解。由ITCH介导的GLI1降解过程不依赖于与beta-TrCP相互作用所需的Dc或Dn降解结构域，而是依赖于GLI1上的新型PPXYs/pSP降解结构域（参见di Marcotullio等，2006，2011；Huntzicker等，2006）。