Concomitant Hydrate Polymorphism in the Precipitation of Sparfloxacin from Aqueous Solution
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The Potentiometric Cycling for Polymorph Creation [PC]2 has been applied to sparfloxacin, a third-generation fluoroquinolone antibiotic. Two different trihydrate phases precipitate from aqueous solution. X-ray data indicate that one of these is a previously unknown polymorph of sparfloxacin trihydrate. Because both forms crystallize from solution at the same time, the two crystalline forms are concomitant polymorphs that precipitate in a thermodynamically controlled ratio.
创建时间：
2016-02-27
