Multi-omics Profiling of Younger Asian Breast Cancers Reveals Distinctive Molecular Signatures
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113184
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We observed higher proportions of HER2+ and Luminal B but lower proportions of ER+ and Luminal A subtypes along with lower estrogen receptor (ER) expression in SMC compared to TCGA. Germline pathogenic mutations affecting BRCA1 or BRCA2 were found in 11% of SMC but only 5% of TCGA. TP53 was also more frequently mutated in SMC (48%) than in TCGA (32%). 178 samples (168 tumors, 10 normals) from whole transcriptome sequencing
创建时间：
2018-06-13
