Effect of constitutive AHR activation in skeletal muscle [AHRmKO_RNAseq]

To investigate the RNA differences in skeletal muscle in muscle-specific AHR (aryl hydrocarbon receptor) knockout mice and their AHR-floxed littermate controls (wildtype) following a 16-week chronic cigarette smoke exposure intervention Overall design: Male AHR-floxed (wildtype) and muscle-specific AHR knockout (AHRmKO) mice were subjected to daily cigarette smoke exposures for 16 weeks. RNA was harvested from the gastrocnemius muscle 72 hours following the final smoke exposure. RNA sequencing was performed to explored transcriptional changes.