To determine how inhibition of BTK synergizes with ASNase, we performed RNA sequencing investigating which genes are affected in response to ASNase, ibrutinib or the combination Nalm6 and Sem cells we
Inhibition of DNA repair enzymes is an attractive target for increasing the efficacy of DNA damaging chemotherapies. The ERCC1-XPF heterodimer is a key endonuclease in numerous single and double stran
Gain at chromosome 17q21 in neuroblastoma and is associated with a poor prognosis, independent of MYCN amplification status. Several potential proto-oncogenes have been identified in this region, one
FMS-like tyrosine kinase 3 (FLT3) is the most frequently mutated gene in acute myeloid leukemia (AML), and is associated with a poor prognosis and high relapse rate. Gilteritinib, as a second-generati
Wyniki badań in vitro sugerują, że supernatant pohodowlany (PM) uzyskany z L. plantarum i L. rhamnosus wydaje się obiecującym narzędziem zwiększającym skuteczność standardowych terapeutyków oraz no
