R2 reported for complex diseases compared to analytic values when marker panel explains one quarter, one half or the full heritability.

Schiz, schizophrenia. MS, multiple sclerosis. BrCa, breast cancer. PrCa, prostate cancer. RA, rheumatoid arthritis. Celiac, celiac disease. MI/CAD, early-onset myocardial infarction or coronary artery disease. T2D, type-2 diabetes. K, population prevalence and h2, heritability of liability taken from Visscher et al [1] and Wray et al [21] except for celiac, assumed equal to RA. π0, proportion of markers assumed to have no effects. Reported R2, highest R2 reported in cited publication, transformed to the liability scale. In parentheses, values achieved by an infinite training sample. Reported , variance explained by markers as estimated in cited publication. , estimated variance explained using method proposed herein.