The original data of the manuscript by Shuwei Zhang and Yantao Zhao.

NMR spectra of two new microbial metabolites of 6S. Anti-inflammatory activity of microbial metabolites of 6S in vitro and in vivo. LC-MS/MS raw data. Gut microbiota-dependent metabolism of 6-shogaol generates bioactive metabolites that drive its anti-inflammatory activity, underscoring the critical role of microbial metabolism in shaping the biological effects of dietary ginger constituents.