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DNA methylation analysis of ferroptotic multiple myeloma cells

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NIAID Data Ecosystem2026-03-13 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE184576
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To investigate ferroptosis-dependent changes in DNA methylation, a genome wide DNA methylation profiling of ferroptotic (RSL3-treated) multiple myeloma cells (MM1S & MM1R) was performed using the 850K MethylationEPIC BeadChip Array. The ferroptotic DNA methylation signature was compared to myeloma cells pre-treated with the ferroptosis inhibitor ferrostatin-1 (FRSL3), which served as a negative control. In total, three biological replicates per treatment per cell line were included. Bisulphite converted DNA from 12 samples (i.e. 3 samples per cell line, per treatment) were hybridised to the Illumina Infinium 850k Human MethylationEPIC Array
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2021-12-09
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