Purpose: To investigate the impact of oncogenic Notch on the 3D genome organization of cancer cells. Methods: We generated cohesin HiChIP and 1D epigenomic data sets in two different Notch-dependent c
Peripheral nerve injuries are common and lead to life-long disability for affected individuals in spite of surgical treatments. Yet an unsolved clinical problem is misdirected...
In order to investigate how NICD2 promotes cyst growth, we carried out bulk RNA-Seq analysis of kidneys from PKD mouse model R26NICD2/+ Pax8-rtTA mice. Overall design: mRNA profiles of 8-week old wild
In murine models, we find that irradiation of Paneth cells caused a gain of a stem cell-like transcriptome and induced activation of the Notch signaling pathway. This study documents plasticity by Pan
Additional file 3: Video S3. Confined endothelial cell collective where juxtacrine Notch signalling is active. Timestamp and scalebar are displayed. Video S4. Confined endothelial cell collective wher
