Role of YAP/TAZ-TEAD in human trophoblast

During placentation, placental cytotrophoblast cells differentiate into syncytiotrophoblast cells and extravillous trophoblast cells. In placenta, the expression of various genes is regulated by the Hippo pathway through the transcriptional coactivator YAP/TAZ-TEAD activity. To examine the effect of YAP/TAZ and/or TEAD on trophoblast differentiation, knockdown experiments were performed. Microarray analysis were performed to identify YAP/TAZ and/or TEAD target genes in human trophoblast. Observation of gene expression changes in human trophoblast stem cells after treatmet with siRNAs targeting YAP/TAZ or TEAD using microarray.