Expression of IFNG-stimulated genes

IFN-gamma stimulates gene expression of about 200 genes which include the primary response genes like IRFs, Fc-gamma receptor (FCGR), GBPs (guanylate-binding proteins) and also major histocompatibility complex (MHC) class I and class II molecules, proteins involved in antigen presentation, antiviral proteins like PKR, OAS proteins etc. A wonderful list of most of the IFN-gamma inducible proteins with corresponding literature are mentioned in the review article and the supplementary document by Boehm et al 1997.

IFN-γ激活约200个基因的表达，其中包含主要反应基因如IRFs、Fc-γ受体（FCGR）、GBP（鸟苷酸结合蛋白）以及主要组织相容性复合体（MHC）I类和II类分子，这些分子涉及抗原呈递，抗病毒蛋白如PKR、OAS蛋白等。Boehm等人在1997年的综述文章及补充文档中列举了大部分由IFN-γ诱导的蛋白清单及其相关文献。