Myelin components can interact with p75NTR:NgR:LINGO1

A group of myelin components named MDGIs (myelin-derived growth-inhibitors), bind to NgR and inhibit neurite outgrowth. Examples of such components are NOGO, OMGP (oligodendrocyte myelin glycoprotein) and MAG (myelin-associated glycoprotein). The amino-terminal region of NgR, covering eight leucine-rich repeats (LRR) and the LRR carboxy-terminal domain (LRRCT) is sufficient to interact with MAG, OMGP and NOGO. Their binding to NgR enhances the NgR-p75 interaction.These inhibitors bind to a receptor complex made up of the NOGO receptor, NgR, and p75NTR. Such complexes then activate RHOA, thereby inhibiting axonal growth.

一组称为髓鞘衍生的生长抑制剂（MDGIs）的髓鞘成分，与NgR结合并抑制轴突生长。此类成分的实例包括NOGO、OMGP（少突胶质细胞髓鞘糖蛋白）和MAG（髓鞘相关糖蛋白）。NgR的氨基末端区域，覆盖八个富含亮氨酸的重复序列（LRR）和LRR羧基末端结构域（LRRCT），足以与MAG、OMGP和NOGO相互作用。它们与NgR的结合增强了NgR-p75相互作用。这些抑制剂与由NOGO受体、NgR和p75NTR组成的受体复合物结合。此类复合物随后激活RHOA，从而抑制轴突生长。