SIRFLOX Study

Interventions: The study intervention will consist of FOLFOX6m chemotherapy plus a single implantation of selective internal radiation therapy in the form of SIR-Spheres microspheres administered on the 3rd day of the first cycle of chemotherapy. The chemotherapy will be administered until treatment failure (as assessed by progression of disease) or until chemotherapy toxicity is reported. Based on preliminary data it is thought that time to progression of disease in the treatment group could be 11 months or more. Primary outcome(s): Progression free survival at any site[Progression to be assessed by CT scan every 2 months.] Study Design: Purpose: Treatment; Allocation: Randomised controlled trial; Masking: Open (masking not used);Assignment: Parallel;Type of endpoint: Efficacy