Number of women recruited per group.

NTD: neural tube defect. * Transverse limb defects (7 cases), bowel atresia (3 cases: duodenal atresia or ileal atresia) . ** Trisomy 21 (10 cases), trisomy 18 (2 cases), 1 case each of trisomy 13, 45 X0, XXX, triploidy, unbalanced translocation, 15q deletion, terminal deletion of chromosome 5. Δ Skeletal dysplasia (8 cases), multiple abnormalities (6 cases), autosomal dominant polycystic kidney disease (2 cases). Cardiac anomalies included large septal defects, hypoplastic left or right heart, Ebstein's anomaly, tetralogy of Fallot, transposition of the great arteries, left atrial isomerism, valvular atresias and double outlet right ventricle. Other CNS anomalies included agenesis of corpus callosum, Dandy Walker spectrum, cerebellar hypoplasia, posterior fossa cyst, porencephalic cyst, severe ventriculomegaly and holoprosencephaly. Renal anomaly: multicystic or dysplastic kidneys, lower urinary outflow tract obstruction. Number of women recruited per group.