Combination immunotherapy can rescue CD8+ T cell dysfunction and maintain memory phenotype in cancer
收藏NIAID Data Ecosystem2026-05-26 收录
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资源简介：
In this study we unveiled specific molecular and cellular mechanisms driving the potent synergism of a coinhibitory antagonist (anti-PD-1 Ab) and a costimulatory agonist (anti-GITR Ab), a modality currently in early clinical testing, and elucidated the parameters required for durable anti-tumor responses. Overall design: Single cell sequencing on CD8 T cells sorted from MC38 mouse colon tumors and spleens treated with Isotype control, aGITR mono, aPD1 mono and aGITR+aPD1 combo on day 8 and 11. MC38 cells were injected subcutaneously into mice.
创建时间：
2019-02-23
