Transcription profiling by array of mouse tissues from different mouse strains to investigate the effects of copy number variation on gene expression

Copy number variation (CNV) of DNA segments has recently been identified as a major source of genetic diversity, but a more comprehensive understanding of the extent and phenotypic effect of this type of variation is only beginning to emerge. In this study we generated genome-wide expression data from 6 mouse tissues to investigate how CNVs influence gene expression. Keywords: genetic background, gene expression profiling C57BL/6J, DBA2/J, AKR/J, A/J and C3HeB/FeJ were purchased from The Jackson Laboratory and 129S2 from Charles River, France. Six tissues were dissected from three males of 11-14 weeks of age, for each strain.DNA片段的拷贝数变异（Copy Number Variation, CNV）近年来被证实为遗传多样性的重要来源之一，但学界对这类变异的波及范围与表型效应的全面认知仍处于初步阶段。本研究通过采集6种小鼠组织的全基因组表达数据，探究CNV对基因表达的影响。关键词：遗传背景、基因表达谱。C57BL/6J、DBA2/J、AKR/J、A/J及C3HeB/FeJ均购自杰克逊实验室（The Jackson Laboratory），129S2品系则购自法国查尔斯河（Charles River）公司。每个品系均选取3只11至14周龄的雄性小鼠，解剖获取6种组织样本。