Quaternary complex of PYCR1 with the allosteric inhibitor 1-benzyl-1H-1,3-benzodiazole-2-sulfonic acid in a remote site and NADH and (S)-tetrahydrofuran-2-carboxylic acid in the active site

Quaternary complex of PYCR1 with the allosteric inhibitor 1-benzyl-1H-1,3-benzodiazole-2-sulfonic acid in a remote site and NADH and (S)-tetrahydrofuran-2-carboxylic acid in the active site Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-benzyl-1H-1,3-benzimidazole-2-sulfonic acid, DI(HYDROXYETHYL)ETHER, ... Authors: Tanner, J.J, Meeks, K.R. Deposit date: 2025-08-19 Release date: 2026-02-04 Last modified: 2026-03-25 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1. Biochem.J., 483, 2026