Dissecting the Neuroprotective Response in Exercise and Alzheimer's Disease at the Single-Cell Level
收藏NIAID Data Ecosystem2026-05-01 收录
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We used single-nuclei RNA-sequencing to systematically dissect the transcriptional adaptive neuroprotective response. We focused on the neurogenic stem cell niche within the dentate gyrus of APP/PS1 transgenic AD mice that exhibited improved cognitive flexibility after exercise with freewheel running. snRNAseq revealed that cell-type-specific responses to exercise were distinct in the wildtype mice and AD mice.
创建时间：
2023-05-25
