Corrias2007_GastricSMCellularActivation

This a model from the article:
A quantitative model of gastric smooth muscle cellular activation.

Corrias A, Buist ML. Ann Biomed Eng
2007 Sep;35(9):1595-607 17486452
,
Abstract:

A physiologically realistic quantitative description of the electrical behavior
of a gastric smooth muscle (SM) cell is presented. The model describes the
response of a SM cell when activated by an electrical stimulus coming from the
network of interstitial cells of Cajal (ICC) and is mediated by the activation
of different ion channels species in the plasma membrane. The conductances
(predominantly Ca2+ and K+) that are believed to substantially contribute to the
membrane potential fluctuations during slow wave activity have been included in
the model. A phenomenological description of intracellular Ca2+ dynamics has
also been included because of its primary importance in regulating a number of
cellular processes. In terms of shape, duration, and amplitude, the resulting
simulated smooth muscle depolarizations (SMDs) are in good agreement with
experimentally recordings from mammalian gastric SM in control and altered
conditions. This model has also been designed to be suitable for incorporation
into large scale multicellular simulations.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Corrias A, Buist ML. (2007) - version02

The original CellML model was created by:
Corrias, Alberto,

[e-mail]
National University of Singapore
Division BioEngineering
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