CIN+ was indicated by the presence of LOH. This was scored for overall CIN+ if a cancer had 1 of the 12 markers showing greater than 40% loss in intensity of one allele compared to its paired normal.

Figshare2015-12-02 更新30

Chromosome copy number changes in Mad2-null-driven p53 null HCC and T-ALL samples. Mus musculus

染色体不稳定性

拷贝数变异分析

Mad2 and p53 loss were combined in liver or T-cells specificely leading to early onset and highly aggressive aneuploid HCC and T-ALL. Tumours were characterized for (recurrrent) copy number changes wi

NIAID Data Ecosystem30

Re-replication of a Centromere Induces Chromosomal Instability and Aneuploidy

染色体不稳定性

非整倍性诱导

The faithful inheritance of chromosomes during cell division requires their precise replication and segregation. Numerous mechanisms ensure that each of these fundamental cell cycle events is performe

NIAID Data Ecosystem40

MACROD2 haploinsufficiency promotes chromosome instability and growth of intestinal tumors

肠道肿瘤转录组学

染色体不稳定性

RNA-Seq data from intestinal tumors of ApcMin/+/Macrod2-/-,ApcMin/+/Macrod2-/+ and ApcMin/+/Macrod2+/+ mice (6 tumors per group) Overall design: Examine mRNA expression level changes between tumors by

NIAID Data Ecosystem30

Re-replication generates whole-chromosomal instability and anueploidy

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