Quantitative indices of a typical inflammatory response curve.

The timing indices (Tact and Ri) and the amount indices (Ψmax and Rp) are defined as follows. Ψmax: peak height for a model output variable (molecular species or cell type); Tmax: time at which a model output variable reaches the peak height value; Tact: time to reach peak height after inflammation initiation; T50: time for a model output variable to decay from its peak height value to 50% of the peak height; Ri: difference between T50 and Tact; Rp: the value of a model output variable at the right-most time point of the simulation, as a percentage of the peak height value.