Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate

NIAID Data Ecosystem2026-05-01 收录

Tfh细胞分化

CD4+T细胞记忆命运

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174104 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2023-08-08

Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1. Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1

Tfh细胞分化

LXR-β/TCF-1通路调控

Liver X receptor (LXR) is a critical regulator of cholesterol homeostasis, and inhibits TCR-induced proliferation by altering intracellular sterol metabolism. However, the mechanisms by which LXR regu

NIAID Data Ecosystem80

Genome binding/occupancy profiling of Tox2 in Tfh-like cells. Genome binding/occupancy profiling of Tox2 in Tfh-like cells

Tfh细胞分化

转录因子结合位点分析

T Follicular helper (Tfh) cell is an effector CD4+ T cell subset specialized in helping B cells in germinal centers (GC) reactions. Although Bcl6 was identified as a Tfh-specific transcription factor

NIAID Data Ecosystem50

ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Mus musculus

Tfh细胞分化

FOXO1转录调控

T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor I

NIAID Data Ecosystem30

Follicular Helper T Cells Progressively Differentiate to Regulate the Germinal Center Response. Mus musculus

Tfh细胞分化

生发中心反应

Purpose: To compare the transcriptomes of IL-21-expressing, IL-21 and IL-4-expressing, and IL-4 expressing follicular helper T (Tfh) cells and Th2 cells in the spleen at 8 days following helminth infe

NIAID Data Ecosystem70

Data_Sheet_1_Comparative Analysis of Global Proteome and Lysine Acetylome Between Naive CD4+ T Cells and CD4+ T Follicular Helper Cells.zip

Tfh细胞分化

蛋白质乙酰化修饰

As a subgroup of CD4+ T helper cells, follicular helper T (Tfh) cells provide help to germinal center B cells and mediate the development of long-lived humoral immunity. Dysregulation of Tfh cells is

NIAID Data Ecosystem40

Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate

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