Processed source data and analysis code for cross-layer benchmarking of SGTA in lung adenocarcinoma

This versioned research compendium contains analysis scripts, processed statistical outputs, figure-level source data, figure previews, provenance records, and audit files supporting a cross-layer benchmark of SGTA in lung adenocarcinoma. Version 1.3.0 adds a dated and frozen 712-gene proteostasis candidate universe, paired RNA and paired-protein effect matrices, two-cohort matched-background benchmarking, cross-layer evidence classification, identity-aware anchor-network preservation with 5,000 protein-label permutations and 2,000 patient bootstraps, a paired lung-squamous-cell-carcinoma histology control, and a prespecified single-cell extension feasibility screen. The results confirm reproducible SGTA protein elevation and local protein-identity preservation but do not support proteostasis-panel specificity, LUAD-histology restriction, malignant-cell specificity, or broad basal fitness dependence. No new primary patient or experimental data were generated. Raw TCGA, GEO, CPTAC/PDC, MSigDB, and DepMap matrices are not redistributed. Original code is licensed under MIT; study-generated processed outputs, figures, provenance, and documentation are licensed under CC BY 4.0.Administrative correction (28 July 2026): Outdated authorship metadata in legacy manuscript-building materials were corrected. This administrative correction does not affect the data, analyses, figures, results, or scientific conclusions.