Individual trial estimates from binary data not combined in meta-analyses.

Legend. Studies are listed in order of increasing length of follow-up, within each category of outcomes. Abbreviations: UK = United Kingdom; RU = Russia; FUP = follow-up; m = months; n = number of patients with events or number of events; N = total number of patients per group; RR = relative risk; CI = confidence intervals; LDL = Low Density Lipoprotein; TC = Total Cholesterol; NT-proBNP = N-terminal pro-brain natriuretic peptide; LASI = left atrium size index; LVEDVI = left ventricular end-diastolic volume index; LVMI = left ventricular mass index; E/A ratio = ratio of early (E) to late (A) mitral valve flow velocity; 6MWT = six minute walk test to measure of functional exercise capacity; mmol/l = millimoles per litre. ¶positive decrease/regression corresponded to less than the upper limit of 95% CI.