Whole-Genome Sequencing of Initiated Tumors Arising from Pre-malignant Epithelium Coinjected with Mesenchymal Stem Cells in an Intrabursal Murine Model

Variant calls and functional analysis from whole-genome sequencing data. Briefly, pre-malignant fallopian tube epithelium was grown as organoids with or without mesenchymal stem/stromal cells (MSCs) extracted from the fallopian tube of germline BRCA-mutant women undergoing prophylactic surgery. Organoids were then implanted in NSG mice and followed for tumor initiation, which only occurred in mice implanted with epi-MSC organoids. The pre-implanted epithelial cells and initiated tumors then underwent whole-genome sequencing.

Sample Key:
Normal - pre-malignant epithelium
S1 - primary tumor from mouse 1
S2 - metastatic tumor from mouse 1
S3 - metastatic tumor from mouse 2

This dataset contains the downstream analysis of our WGS data, specifically variant calls.