C1q-TNF-Related Protein-9 protects from diabetic cardiomyopathy by alleviating cardiac insulin resistance and inflammation

Diabetic cardiomyopathy is a major health problem world wide. CTRP9 is a secreted glycoprotein, which is mainly expressed in endothelial cells of the heart. In this study, we investigated the impact of CTRP9 on diabetic cardiomyopathy induced by high fat diet feeding. While the lack of CTRP9 in knock-out mice aggravated the disease, AAV9 mediated cardiac CTRP9 overexpression ameliorated diastolic cardiac dysfunction under these conditions. Mechanistically, we found that CTRP9 is required for insulin dependent cardiac glucose uptake and metabolism and that it counteracts cardiac inflammation. Bulk RNA sequencing from ehole heart tissue of WT and CTRP9-KO mouse after high fat diet. For overexpression approach, injection of AAV was performed. (AAV Luciferase and AAV-CTRP9)