RNA binding proteins (RBP) of the ZFP36 family limit the differentiation and effector functions of CD4 and CD8 T cells, but little is known of their expression or function in regulatory T cells (Treg)

NIAID Data Ecosystem50

Transcriptome analysis of antigen-specific T follicular helper (Tfh) and non-Tfh cells after Bach2 overexpression. Transcriptome analysis of antigen-specific T follicular helper (Tfh) and non-Tfh cells after Bach2 overexpression

T细胞免疫调节

转录组学分析

We identified Bach2 as factor to be expressed at low levels in Tfh cells. Induced overexpression of Bach2 in the germinal center reaction results in loss of the Tfh cell population. RNA-seq of sorted

NIAID Data Ecosystem40

Effect of Disulfiram on T cell activation

T细胞免疫调节

药物机制研究

To determine the effect of DSF on T cell activation ,we treated T cells with DSF and analyzed their functions. Comparative gene expression profiling analysis of RNA-seq for T cells after treated with

NIAID Data Ecosystem60

Role of interleukin 2 on Foxp3+CD4+ regulatory T (Treg) cell gene expression and chromatin modeling in thymus and lymph node, and on SATB1 DNA binding in single positive CD4 thymocytes

T细胞免疫调节

表观基因组学

Interleukine 2 (IL-2) is still one of the most interesting cytokines in T cell biology with its ability to control immune homeostasis by maintaining the functional identity of Foxp3+ regulatory T (Tre

NIAID Data Ecosystem40

Store-operated Ca2+ entry in follicular T cells controls humoral immune responses and autoimmunity

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